• Senior leader Issam Bazzi is leaving Point72's quant unit, Cubist, after three years.
• Bazzi's team had been in the red, with trading losses in the tens of millions.
• The change comes several months after a shake-up at the top of Cubist.

A senior leader at the quant division of $46 billion hedge fund Point72 Asset Management is leaving the firm, according to people familiar with the matter.

Issam Bazzi, a senior quant who helped lead the buildout of a centralized trading unit at Cubist Systematic Strategies, is out after nearly three years at the hedge fund.

Bazzi's team had struggled performance-wise for months and had been down as much as $70 million this year, Business Insider has learned.

A Point72 representative declined to comment. Bazzi did not immediately respond to requests for comment.

Bazzi's exit comes several months after a surprising leadership shake-up at the top of Cubist, with president Denis Dancanet leaving and ex-WorldQuant exec Geoffrey Lauprete taking his place.

Building a centralized trading unit, akin to a traditional collaborative quant fund, to trade alongside the dozens of independent pods was a key initiative for Dancanet when he joined in 2020. The firm spent tens of millions luring top talent, but none more significant than Bazzi, a Citadel Securities veteran who also overlapped with Dancanet at quant hedge fund PDT.

Amid the changes last September, Bazzi's fate at the firm was fodder for market chatter, but in October, he and billionaire founder Steve Cohen negotiated a deal for him to stay on, Business Insider previously reported.

This story is developing.